| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PSEN2 |
| Gene ID: | 5664 |
| Uniprot ID: | PSN2_HUMAN |
| Immunogen Region: | 267-448 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 267-384 of human PSEN2 (NP_000438.2). |
| Immunogen Sequence: | VLCPKGPLRMLVETAQERNE PIFPALIYSSAMVWTVGMAK LDPSSQGALQLPYDPEMEED SYDSFGEPSYPEVFEPPLTG YPGEELEEEEERGVKLGLGD FIFYSVLVGKAAATGSGD |
| Tissue Specificity | Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney. |
| Post Translational Modifications | Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments. Phosphorylated on serine residues. |
| Function | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria. |
| Protein Name | Presenilin-2Ps-2Ad3lpAd5E5-1Stm-2 Cleaved Into - Presenilin-2 Ntf Subunit - Presenilin-2 Ctf Subunit |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-193692Reactome: R-HSA-205043Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-3928665Reactome: R-HSA-9013507Reactome: R-HSA-9013700Reactome: R-HSA-9017802Reactome: R-HSA-9839383 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Presenilin-2 antibodyAnti-Ps-2 antibodyAnti-Ad3lp antibodyAnti-Ad5 antibodyAnti-E5-1 antibodyAnti-Stm-2 Cleaved Into - Presenilin-2 Ntf Subunit - Presenilin-2 Ctf Subunit antibodyAnti-PSEN2 antibodyAnti-AD4 antibodyAnti-PS2 antibodyAnti-PSNL2 antibodyAnti-STM2 antibody |
Information sourced from Uniprot.org
