Anti-PSEN2 antibody (1-50) {Biotin} (STJ502679)

SKU:
STJ502679-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Monkey/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PSEN2 (1-50) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 1.00-1.25 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PSEN2
Gene ID: 5664
Uniprot ID: PSN2_HUMAN
Immunogen Region: 1-50
Immunogen: Synthetic peptide taken within amino acid region 1-50 on human Presenilin-2 protein.
Tissue Specificity Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
Post Translational Modifications Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments. Phosphorylated on serine residues.
Function Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.
Protein Name Presenilin-2
Ps-2
Ad3lp
Ad5
E5-1
Stm-2 Cleaved Into - Presenilin-2 Ntf Subunit - Presenilin-2 Ctf Subunit
Database Links Reactome: R-HSA-1251985
Reactome: R-HSA-193692
Reactome: R-HSA-205043
Reactome: R-HSA-2122948
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-2979096
Reactome: R-HSA-3928665
Reactome: R-HSA-9013507
Reactome: R-HSA-9013700
Reactome: R-HSA-9017802
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Golgi Apparatus Membrane
Alternative Antibody Names Anti-Presenilin-2 antibody
Anti-Ps-2 antibody
Anti-Ad3lp antibody
Anti-Ad5 antibody
Anti-E5-1 antibody
Anti-Stm-2 Cleaved Into - Presenilin-2 Ntf Subunit - Presenilin-2 Ctf Subunit antibody
Anti-PSEN2 antibody
Anti-AD4 antibody
Anti-PS2 antibody
Anti-PSNL2 antibody
Anti-STM2 antibody

Information sourced from Uniprot.org

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