Anti-PSD93 antibody [R02-4E7] (STJA0035336)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human PSD93
General Information
| Short Description | Rabbit monoclonal anti-PSD93 for use in WB and IP in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R02-4E7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | DLG2 |
| Gene ID | 1740 |
| Uniprot ID | DLG2_HUMAN |
| Immunogen | A synthetic peptide of human PSD93 |
Additional Info
| Post Translational Modifications | Palmitoylation of isoform 1 is not required for targeting to postsynaptic density. |
| Function | Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. |
| Protein Name | Disks Large Homolog 2Channel-Associated Protein Of Synapse-110Chapsyn-110Postsynaptic Density Protein Psd-93 |
| Database Links | Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-6794361Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneLipid-AnchorPostsynaptic DensitySynapseMembraneCell ProjectionAxonPerikaryonConcentrated In Soma And Postsynaptic Density Of A Subset Of Neurons |
| Alternative Antibody Names | Anti-Disks Large Homolog 2 antibodyAnti-Channel-Associated Protein Of Synapse-110 antibodyAnti-Chapsyn-110 antibodyAnti-Postsynaptic Density Protein Psd-93 antibodyAnti-DLG2 antibody |
Information sourced from Uniprot.org