| Post Translational Modifications | Palmitoylation of isoform 1 is not required for targeting to postsynaptic density. |
| Function | Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. |
| Protein Name | Disks Large Homolog 2Channel-Associated Protein Of Synapse-110Chapsyn-110Postsynaptic Density Protein Psd-93 |
| Database Links | Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-6794361Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneLipid-AnchorPostsynaptic DensitySynapseMembraneCell ProjectionAxonPerikaryonConcentrated In Soma And Postsynaptic Density Of A Subset Of Neurons |
| Alternative Antibody Names | Anti-Disks Large Homolog 2 antibodyAnti-Channel-Associated Protein Of Synapse-110 antibodyAnti-Chapsyn-110 antibodyAnti-Postsynaptic Density Protein Psd-93 antibodyAnti-DLG2 antibody |
Information sourced from Uniprot.org
