Anti-PRSS8 antibody [R03-4J4] (STJA0034765)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human PRSS8
General Information
| Short Description | Rabbit monoclonal anti-PRSS8 for use in WB and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-4J4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PRSS8 |
| Gene ID | 5652 |
| Uniprot ID | PRSS8_HUMAN |
| Immunogen | Recombinant protein of human PRSS8 |
Additional Info
| Tissue Specificity | Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid. |
| Function | Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). |
| Protein Name | ProstasinChannel-Activating Protease 1Cap1Serine Protease 8 Cleaved Into - Prostasin Light Chain - Prostasin Heavy Chain |
| Database Links | Reactome: R-HSA-6809371 |
| Cellular Localisation | Prostasin: Cell MembraneSingle-Pass Membrane ProteinProstasin Light Chain: SecretedExtracellular SpaceFound In The Seminal FluidSecreted After Cleavage Of Its C-TerminusProstasin Heavy Chain: Secreted |
| Alternative Antibody Names | Anti-Prostasin antibodyAnti-Channel-Activating Protease 1 antibodyAnti-Cap1 antibodyAnti-Serine Protease 8 Cleaved Into - Prostasin Light Chain - Prostasin Heavy Chain antibodyAnti-PRSS8 antibody |
Information sourced from Uniprot.org