| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRSS2 |
| Gene ID: | 5645 |
| Uniprot ID: | TRY2_HUMAN |
| Immunogen Region: | 24-247 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human PRSS2 (NP_002761.1). |
| Immunogen Sequence: | IVGGYICEENSVPYQVSLNS GYHFCGGSLISEQWVVSAGH CYKSRIQVRLGEHNIEVLEG NEQFINAAKIIRHPKYNSRT LDNDILLIKLSSPAVINSRV SAISLPTAPPAAGTESLISG WGNTLSSGADYPDELQCLDA PVLSQAECEASYPGKITNNM FCVGFLEGGKDSCQGDSGGP VVSNGELQGIVSWGYGCAQK NRPGVYTKVYNYVDWIKDTI AANS |
| Tissue Specificity | Expressed in Paneth cells, at the base of small intestinal crypts. |
| Post Translational Modifications | Sulfated on tyrosine. Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins. |
| Function | In the ileum, may be involved in defensin processing, including DEFA5. |
| Protein Name | Trypsin-2 Anionic Trypsinogen Serine Protease 2 Trypsin Ii |
| Database Links | Reactome: R-HSA-1442490 Reactome: R-HSA-1462054 Reactome: R-HSA-1592389 Reactome: R-HSA-6798695 Reactome: R-HSA-6803157 |
| Cellular Localisation | Secreted Extracellular Space |
| Alternative Antibody Names | Anti-Trypsin-2 antibody Anti-Anionic Trypsinogen antibody Anti-Serine Protease 2 antibody Anti-Trypsin Ii antibody Anti-PRSS2 antibody Anti-TRY2 antibody Anti-TRYP2 antibody |
Information sourced from Uniprot.org