• Western blot analysis of extracts of various cell lines, using PRSS2 antibody (STJ110232) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
  • Western blot analysis of extracts of various cell lines, using PRSS2 antibody (STJ110232) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-PRSS2 antibody (24-247) (STJ110232)

SKU:
STJ110232

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PRSS2 (24-247) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PRSS2
Gene ID: 5645
Uniprot ID: TRY2_HUMAN
Immunogen Region: 24-247
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human PRSS2 (NP_002761.1).
Immunogen Sequence: IVGGYICEENSVPYQVSLNS GYHFCGGSLISEQWVVSAGH CYKSRIQVRLGEHNIEVLEG NEQFINAAKIIRHPKYNSRT LDNDILLIKLSSPAVINSRV SAISLPTAPPAAGTESLISG WGNTLSSGADYPDELQCLDA PVLSQAECEASYPGKITNNM FCVGFLEGGKDSCQGDSGGP VVSNGELQGIVSWGYGCAQK NRPGVYTKVYNYVDWIKDTI AANS
Tissue Specificity Expressed in Paneth cells, at the base of small intestinal crypts.
Post Translational Modifications Sulfated on tyrosine. Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.
Function In the ileum, may be involved in defensin processing, including DEFA5.
Protein Name Trypsin-2
Anionic Trypsinogen
Serine Protease 2
Trypsin Ii
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1462054
Reactome: R-HSA-1592389
Reactome: R-HSA-6798695
Reactome: R-HSA-6803157
Cellular Localisation Secreted
Extracellular Space
Alternative Antibody Names Anti-Trypsin-2 antibody
Anti-Anionic Trypsinogen antibody
Anti-Serine Protease 2 antibody
Anti-Trypsin Ii antibody
Anti-PRSS2 antibody
Anti-TRY2 antibody
Anti-TRYP2 antibody

Information sourced from Uniprot.org

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