Anti-PRSS2 antibody (1-100) [S6MR] (STJ11103006)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal PRSS2 (1-100) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S6MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:2000-1:6000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRSS2 |
| Gene ID | 5645 |
| Uniprot ID | TRY2_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MNLLLILTFVAAAVAAPFDD DDKIVGGYICEENSVPYQVS LNSGYHFCGGSLISEQWVVS AGHCYKSRIQVRLGEHNIEV LEGNEQFINAAKIIRHPKYN |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PRSS2 (P07478). |
Additional Info
| Tissue Specificity | Expressed in Paneth cells, at the base of small intestinal crypts. |
| Post Translational Modifications | Sulfated on tyrosine. Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins. |
| Function | In the ileum, may be involved in defensin processing, including DEFA5. |
| Protein Name | Trypsin-2Anionic TrypsinogenSerine Protease 2Trypsin Ii |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1462054Reactome: R-HSA-1592389Reactome: R-HSA-6798695Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Trypsin-2 antibodyAnti-Anionic Trypsinogen antibodyAnti-Serine Protease 2 antibodyAnti-Trypsin Ii antibodyAnti-PRSS2 antibodyAnti-TRY2 antibodyAnti-TRYP2 antibody |
Information sourced from Uniprot.org