Anti-PRSS1 antibody (24-247) (STJ25163)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PRSS1 (24-247) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRSS1 |
| Gene ID | 5644 |
| Uniprot ID | TRY1_HUMAN |
| Immunogen Region | 24-247 |
| Immunogen Sequence | IVGGYNCEENSVPYQVSLNS GYHFCGGSLINEQWVVSAGH CYKSRIQVRLGEHNIEVLEG NEQFINAAKIIRHPQYDRKT LNNDIMLIKLSSRAVINARV STISLPTAPPATGTKCLISG WGNTASSGADYPDELQCLDA PVLSQAKCEASYPGKITSNM FCVGFLEGGKDSCQGDSGGP VVCNGQLQGVVSWGDGCAQK NKPGVYTKVYNYVKWIKNTI AANS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human PRSS1 (NP_002760.1). |
Additional Info
| Post Translational Modifications | Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122. Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins. |
| Function | Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates. |
| Protein Name | Serine Protease 1Anionic Trypsin IAnionic Trypsin-IBeta-TrypsinCationic TrypsinogenPretrypsinogen ITrypsin ITrypsin-1 Cleaved Into - Alpha-Trypsin Chain 1 - Alpha-Trypsin Chain 2 |
| Database Links | Reactome: R-HSA-1592389Reactome: R-HSA-9758881Reactome: R-HSA-9925561 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Serine Protease 1 antibodyAnti-Anionic Trypsin I antibodyAnti-Anionic Trypsin-I antibodyAnti-Beta-Trypsin antibodyAnti-Cationic Trypsinogen antibodyAnti-Pretrypsinogen I antibodyAnti-Trypsin I antibodyAnti-Trypsin-1 Cleaved Into - Alpha-Trypsin Chain 1 - Alpha-Trypsin Chain 2 antibodyAnti-PRSS1 antibodyAnti-TRP1 antibodyAnti-TRY1 antibodyAnti-TRYP1 antibody |
Information sourced from Uniprot.org