Anti-PRRX1 antibody (30-110 aa) (STJ95239)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from PRX1 at the amino acid range 30-110
General Information
| Short Description | Rabbit polyclonal anti-Paired mesoderm homeobox protein 1 (30-110 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRRX1 |
| Gene ID | 5396 |
| Uniprot ID | PRRX1_HUMAN |
| Immunogen | Synthesized peptide derived from PRX1 at the amino acid range 30-110 |
| Immunogen Region | 30-110 aa |
| Specificity | PRX1 Polyclonal Antibody detects endogenous levels of PRX1 protein. |
Additional Info
| Function | Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process. Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer. May play a role in homeostasis and regeneration of bone, white adipose tissue and derm. Isoform 1: Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain. Isoform 2: Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines. |
| Protein Name | Paired Mesoderm Homeobox Protein 1Homeobox Protein Phox1Paired-Related Homeobox Protein 1Prx-1 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Paired Mesoderm Homeobox Protein 1 antibodyAnti-Homeobox Protein Phox1 antibodyAnti-Paired-Related Homeobox Protein 1 antibodyAnti-Prx-1 antibodyAnti-PRRX1 antibodyAnti-PMX1 antibody |
Information sourced from Uniprot.org