Anti-PRR7 antibody [TRAP3/10] (STJ16103388)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
ImmunogenRecombinant C-terminal half of the intracellular domain of human PRR7/TRAP3 (amino acids 126-253)
General Information
| Short Description | Mouse monoclonal anti-PRR7 for use in WB and ICC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | TRAP3/10 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by protein-A affinity chromatography. |
| Formulation | Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | PRR7 |
| Gene ID | 80758 |
| Uniprot ID | PRR7_HUMAN |
| Immunogen | Recombinant C-terminal half of the intracellular domain of human PRR7/TRAP3 (amino acids 126-253) |
Additional Info
| Post Translational Modifications | Palmitoylated. Tyrosine phosphorylated, possibly by SRC. |
| Function | Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner. Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN. Might play a redundant role in the regulation of T cell receptor signaling. Might promote apoptosis in T cells. |
| Protein Name | Proline-Rich Protein 7Synaptic Proline-Rich Membrane Protein |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane ProteinPostsynaptic Cell MembranePostsynaptic Density MembraneCytoplasmPerinuclear RegionSynapseCell ProjectionDendriteNucleusEnriched In Postsynaptic Plasma Membrane And Postsynaptic Densities (Psd)Accumulates In Spines Along With Synapse Maturation And Colocalizes With Dlg4 In A Punctate PatternTranslocates From Synapses To Nuclei Following Nmda Receptor Activity |
| Alternative Antibody Names | Anti-Proline-Rich Protein 7 antibodyAnti-Synaptic Proline-Rich Membrane Protein antibodyAnti-PRR7 antibody |
Information sourced from Uniprot.org