Anti-PRPH antibody [ZN202] (STJA0033371)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenFull length human recombinant protein of human PRPH (NP_006253) produced in HEK293T cell.
General Information
| Short Description | Mouse monoclonal anti-PRPH for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ZN202 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 0.5-1.0 mg/mL |
| Purification | Affinity Chromatography |
| Dilution Range | IHC 1:50-1:100 |
| Formulation | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PRPH |
| Gene ID | 5630 |
| Uniprot ID | PERI_HUMAN |
| Immunogen | Full length human recombinant protein of human PRPH (NP_006253) produced in HEK293T cell. |
Additional Info
| Tissue Specificity | Expressed in the neurons of the outer hair cells in the organ of Corti and to a lesser extent in type I spiral ganglion cells. |
| Post Translational Modifications | Phosphorylated.phosphorylation increases after nerve injury in regenerating neurons. |
| Function | Class-III neuronal intermediate filament protein. May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network. Assembly of the neuronal intermediate filaments may be regulated by RAB7A. Plays a role in the development of unmyelinated sensory neurons. May be involved in axon elongation and axon regeneration after injury. Inhibits neurite extension in type II spiral ganglion neurons in the cochlea. |
| Protein Name | PeripherinNeurofilament 4 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionAxonPerikaryon |
| Alternative Antibody Names | Anti-Peripherin antibodyAnti-Neurofilament 4 antibodyAnti-PRPH antibodyAnti-NEF4 antibodyAnti-PRPH1 antibody |
Information sourced from Uniprot.org