Anti-PRPH antibody (421-470 aa) (STJ95235)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Peripherin at the amino acid range 421-470
General Information
| Short Description | Rabbit polyclonal anti-Peripherin (421-470 aa) for use in WB, IHC, IF and ELISA in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRPH |
| Gene ID | 5630 |
| Uniprot ID | PERI_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Peripherin at the amino acid range 421-470 |
| Immunogen Region | 421-470 aa |
| Specificity | PRPH Polyclonal Antibody detects endogenous levels of PRPH protein. |
Additional Info
| Post Translational Modifications | Phosphorylated.phosphorylation increases after nerve injury in regenerating neurons. |
| Function | Class-III neuronal intermediate filament protein. May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network. Assembly of the neuronal intermediate filaments may be regulated by RAB7A. Plays a role in the development of unmyelinated sensory neurons. May be involved in axon elongation and axon regeneration after injury. Inhibits neurite extension in type II spiral ganglion neurons in the cochlea. |
| Protein Name | PeripherinNeurofilament 4 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionAxonPerikaryon |
| Alternative Antibody Names | Anti-Peripherin antibodyAnti-Neurofilament 4 antibodyAnti-PRPH antibodyAnti-NEF4 antibodyAnti-PRPH1 antibody |
Information sourced from Uniprot.org