| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PRPH (1-260) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PRPH |
| Gene ID: |
5630 |
| Uniprot ID: |
PERI_HUMAN |
| Immunogen Region: |
1-260 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PRPH (NP_006253.2). |
| Immunogen Sequence: |
MSHHPSGLRAGFSSTSYRRT FGPPPSLSPGAFSYSSSSRF SSSRLLGSASPSSSVRLGSF RSPRAGAGALLRLPSERLDF SMAEALNQEFLATRSNEKQE LQELNDRFANFIEKVRFLEQ QNAALRGELSQARGQEPARA DQLCQQELRELRRELELLGR ERDRVQVERDGLAEDLAALK QRLEEETRKREDAEHNLVLF RKDVDDATLSRLELERKIES LMDEIEFLKKLHEEELRDL |
| Tissue Specificity | Expressed in the neurons of the outer hair cells in the organ of Corti and to a lesser extent in type I spiral ganglion cells. |
| Post Translational Modifications | Phosphorylated.phosphorylation increases after nerve injury in regenerating neurons. |
| Function | Class-III neuronal intermediate filament protein. May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network. Assembly of the neuronal intermediate filaments may be regulated by RAB7A. Plays a role in the development of unmyelinated sensory neurons. May be involved in axon elongation and axon regeneration after injury. Inhibits neurite extension in type II spiral ganglion neurons in the cochlea. |
| Protein Name | PeripherinNeurofilament 4 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionAxonPerikaryon |
| Alternative Antibody Names | Anti-Peripherin antibodyAnti-Neurofilament 4 antibodyAnti-PRPH antibodyAnti-NEF4 antibodyAnti-PRPH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
