Anti-PRPF8 antibody (STJA0037480)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenPeptide
General Information
| Short Description | Rabbit monoclonal anti-PRPF8 for use in WB, IHC-F, IHC-P, ICC, IF and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-F/IHC-P/ICC/IF/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB-1:1000-1:5000IHC-P-1:200-1:2000ICC/IF-1:50-1:100FC-1:50-1:100 |
| Formulation | Liquid in 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PRPF8 |
| Gene ID | 10594 |
| Uniprot ID | PRP8_HUMAN |
| Immunogen | Peptide |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. |
| Protein Name | Pre-Mrna-Processing-Splicing Factor 8220 Kda U5 Snrnp-Specific ProteinPrp8 HomologSplicing Factor Prp8P220 |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72165 |
| Cellular Localisation | NucleusNucleus Speckle |
| Alternative Antibody Names | Anti-Pre-Mrna-Processing-Splicing Factor 8 antibodyAnti-220 Kda U5 Snrnp-Specific Protein antibodyAnti-Prp8 Homolog antibodyAnti-Splicing Factor Prp8 antibodyAnti-P220 antibodyAnti-PRPF8 antibodyAnti-PRPC8 antibody |
Information sourced from Uniprot.org