Anti-PRPF6 antibody (592-941) (STJ119316)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PRPF6 (592-941) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRPF6 |
| Gene ID | 24148 |
| Uniprot ID | PRP6_HUMAN |
| Immunogen Region | 592-941 |
| Immunogen Sequence | SLEALLQRAVAHCPKAEVLW LMGAKSKWLAGDVPAARSIL ALAFQANPNSEEIWLAAVKL ESENDEYERARRLLAKARSS APTARVFMKSVKLEWVQDNI RAAQDLCEEALRHYEDFPKL WMMKGQIEEQKEMMEKAREA YNQGLKKCPHSTPLWLLLSR LEEKIGQLTRARAILEKSRL KNPKNPGLWLESVRLEYRAG LKNIANTLMAKALQECPNSG ILWSEAIFLEARPQRRTKS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 592-941 of human PRPF6 (NP_036601.2). |
Additional Info
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylated by PRP4K during spliceosome assembly. |
| Function | Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. |
| Protein Name | Pre-Mrna-Processing Factor 6Androgen Receptor N-Terminal Domain-Transactivating Protein 1Ant-1Prp6 HomologU5 Snrnp-Associated 102 Kda ProteinU5-102 Kda Protein |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72165 |
| Cellular Localisation | NucleusNucleoplasmNucleus SpeckleLocalized In Splicing Speckles |
| Alternative Antibody Names | Anti-Pre-Mrna-Processing Factor 6 antibodyAnti-Androgen Receptor N-Terminal Domain-Transactivating Protein 1 antibodyAnti-Ant-1 antibodyAnti-Prp6 Homolog antibodyAnti-U5 Snrnp-Associated 102 Kda Protein antibodyAnti-U5-102 Kda Protein antibodyAnti-PRPF6 antibodyAnti-C20orf14 antibody |
Information sourced from Uniprot.org