Anti-Protein Jumonji antibody [R06-1K4] (STJA0034493)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Jarid2
General Information
| Short Description | Rabbit monoclonal anti-Protein Jumonji for use in WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R06-1K4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | JARID2 |
| Gene ID | 3720 |
| Uniprot ID | JARD2_HUMAN |
| Immunogen | A synthetic peptide of human Jarid2 |
Additional Info
| Tissue Specificity | During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells. |
| Function | Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. Does not have histone demethylase activity. |
| Protein Name | Protein JumonjiJumonji/Arid Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-212300 |
| Cellular Localisation | NucleusColocalizes With The Prc2 Complex On Chromatin |
| Alternative Antibody Names | Anti-Protein Jumonji antibodyAnti-Jumonji/Arid Domain-Containing Protein 2 antibodyAnti-JARID2 antibodyAnti-JMJ antibody |
Information sourced from Uniprot.org