Anti-proSAAS antibody (Internal) (STJ73063)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-proSAAS (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:1000.WB: Preliminary experiments in Human Brain and Pancreas lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml).IHC: Paraffin embedded Human Pancrea |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PCSK1N |
| Gene ID | 27344 |
| Uniprot ID | PCS1N_HUMAN |
| Accession Number | NP_037403.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | EAGDETPDVDPE |
Additional Info
| Post Translational Modifications | Proteolytically cleaved in the Golgi. O-glycosylated with a core 1 or possibly core 8 glycan. |
| Function | May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. Big LEN: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. PEN: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. |
| Protein Name | ProsaasProprotein Convertase Subtilisin/Kexin Type 1 InhibitorProprotein Convertase 1 InhibitorPro-Saas Cleaved Into - Kep - Big SaasB-Saas - Little SaasL-SaasN-Prosaas - Big Pen-LenB-Pen-LenSaas Ct(1-49 - Pen - Little LenL-Len - Big LenB-LenSaas Ct(25-40 |
| Cellular Localisation | SecretedGolgi ApparatusTrans-Golgi NetworkA N-Terminal Processed PeptideProbably Big Saas Or Little SaasIs Accumulated In Cytoplasmic Protein Tau Deposits In Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 (Pick Disease)Alzheimer Disease And Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1 (Guam Disease) |
| Alternative Antibody Names | Anti-Prosaas antibodyAnti-Proprotein Convertase Subtilisin/Kexin Type 1 Inhibitor antibodyAnti-Proprotein Convertase 1 Inhibitor antibodyAnti-Pro-Saas Cleaved Into - Kep - Big Saas antibodyAnti-B-Saas - Little Saas antibodyAnti-L-Saas antibodyAnti-N-Prosaas - Big Pen-Len antibodyAnti-B-Pen-Len antibodyAnti-Saas Ct(1-49 - Pen - Little Len antibodyAnti-L-Len - Big Len antibodyAnti-B-Len antibodyAnti-Saas Ct(25-40 antibodyAnti-PCSK1N antibody |
Information sourced from Uniprot.org