![Anti-PROM1 antibody [3F10] (STJ97904)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/120053/229507/STJ97904_3_ELISA__73443.1602854411.jpg?c=1 "Anti-PROM1 antibody [3F10] (STJ97904)")
Anti-PROM1 antibody [3F10] (STJ97904)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenSynthesized peptide of human CD133.
General Information
| Short Description | Mouse monoclonal anti-Prominin-1 for use in IHC, IF, FC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/FC/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3F10 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | IHC 1:200-1:1000FC 1:200-1:400ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PROM1 |
| Gene ID | 8842 |
| Uniprot ID | PROM1_HUMAN |
| Immunogen | Synthesized peptide of human CD133. |
| Specificity | CD133 Monoclonal Antibody detects endogenous levels of CD133 protein. |
Additional Info
| Post Translational Modifications | Isoform 1 and isoform 2 are glycosylated. Acetylation at Lys-225, Lys-257 and Lys-264 by NAT8 and NAT8B may control PROM1 protein expression and its function in cell apoptosis. |
| Function | May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. |
| Protein Name | Prominin-1Antigen Ac133Prominin-Like Protein 1Cd Antigen Cd133 |
| Database Links | |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell ProjectionMicrovillus MembraneCiliumPhotoreceptor Outer SegmentEndoplasmic ReticulumEndoplasmic Reticulum-Golgi Intermediate CompartmentFound In Extracellular Membrane Particles In Various Body Fluids Such As Cerebrospinal FluidSalivaSeminal Fluid And Urine |
| Alternative Antibody Names | Anti-Prominin-1 antibodyAnti-Antigen Ac133 antibodyAnti-Prominin-Like Protein 1 antibodyAnti-Cd Antigen Cd133 antibodyAnti-PROM1 antibodyAnti-PROML1 antibodyAnti-MSTP061 antibody |
Information sourced from Uniprot.org