Anti-Pro--BDNF antibody (STJ13100048)

SKU:
STJ13100048-500

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Host: NZ White Rabbit
Applications: IHC/WB
Reactivity: Mouse/Rat/Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Nz White Rabbit polyclonal antibody anti-Pro--BDNF is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Shipped as lyophilised. Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.
Purification: Ammonium sulphate precipitation
Dilution Range: A concentration 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: BDNF
Gene ID: 627
Uniprot ID: BDNF_HUMAN
Specificity: Specific for proBDNF.
Immunogen: A synthetic peptide from mouse pro BDNF conjugated to blue carrier protein was used as the antigen.
Post Translational Modifications BDNF precursor form: N-glycosylated and glycosulfated, contrary to mature BDNF. Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG).
Function Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. BDNF precursor form: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse.
Protein Name Brain-Derived Neurotrophic Factor
Bdnf
Abrineurin Cleaved Into - Bdnf Precursor Form
Probdnf
Database Links Reactome: R-HSA-9022702
Reactome: R-HSA-9024909
Reactome: R-HSA-9026519
Reactome: R-HSA-9026527
Reactome: R-HSA-9028335
Reactome: R-HSA-9028731
Reactome: R-HSA-9032500
Reactome: R-HSA-9032759
Reactome: R-HSA-9032845
Reactome: R-HSA-9768919
Cellular Localisation Secreted
Bdnf Precursor Form: Secreted
A Proportion Of Bdnf Is Secreted As Immature Precursor (Probdnf)
Alternative Antibody Names Anti-Brain-Derived Neurotrophic Factor antibody
Anti-Bdnf antibody
Anti-Abrineurin Cleaved Into - Bdnf Precursor Form antibody
Anti-Probdnf antibody
Anti-BDNF antibody

Information sourced from Uniprot.org

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