Anti-PRNP antibody (STJ192113)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Major prion protein for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRNP |
| Gene ID | 5621 |
| Uniprot ID | PRIO_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | PRIO Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains. |
| Protein Name | Major Prion ProteinPrpAscrPrp27-30Prp33-35cCd Antigen Cd230 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-9609523 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorGolgi ApparatusTargeted To Lipid Rafts Via Association With The Heparan Sulfate Chains Of Gpc1ColocatesIn The Presence Of Cu(2+)To Vesicles In Para- And Perinuclear RegionsWhere Both Proteins Undergo InternalizationHeparin Displaces Prnp From Lipid Rafts And Promotes Endocytosis |
| Alternative Antibody Names | Anti-Major Prion Protein antibodyAnti-Prp antibodyAnti-Ascr antibodyAnti-Prp27-30 antibodyAnti-Prp33-35c antibodyAnti-Cd Antigen Cd230 antibodyAnti-PRNP antibodyAnti-ALTPRP antibodyAnti-PRIP antibodyAnti-PRP antibody |
Information sourced from Uniprot.org