| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PRMT7 (513-692) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PRMT7 |
| Gene ID: |
54496 |
| Uniprot ID: |
ANM7_HUMAN |
| Immunogen Region: |
513-692 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 513-692 of human PRMT7 (NP_061896.1). |
| Immunogen Sequence: |
QAASLHAVVVEFRDLWRIRS PCGDCEGFDVHIMDDMIKRA LDFRESREAEPHPLWEYPCR SLSEPWQILTFDFQQPVPLQ PLCAEGTVELRRPGQSHAAV LWMEYHLTPECTLSTGLLEP ADPEGGCCWNPHCKQAVYFF SPAPDPRALLGGPRTVSYAV EFHPDTGDIIMEFRHADTPD |
| Function | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3).such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro.the relevance of such results is however unclear in vivo. |
| Protein Name | Protein Arginine N-Methyltransferase 7Histone-Arginine N-Methyltransferase Prmt7Myelin Basic Protein-Arginine N-Methyltransferase Prmt7 |
| Database Links | Reactome: R-HSA-3214858 |
| Cellular Localisation | CytoplasmCytosolNucleus |
| Alternative Antibody Names | Anti-Protein Arginine N-Methyltransferase 7 antibodyAnti-Histone-Arginine N-Methyltransferase Prmt7 antibodyAnti-Myelin Basic Protein-Arginine N-Methyltransferase Prmt7 antibodyAnti-PRMT7 antibodyAnti-KIAA1933 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
