Anti-PRMT7 antibody (513-692) (STJ114052)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PRMT7 (513-692) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRMT7 |
| Gene ID | 54496 |
| Uniprot ID | ANM7_HUMAN |
| Immunogen Region | 513-692 |
| Immunogen Sequence | QAASLHAVVVEFRDLWRIRS PCGDCEGFDVHIMDDMIKRA LDFRESREAEPHPLWEYPCR SLSEPWQILTFDFQQPVPLQ PLCAEGTVELRRPGQSHAAV LWMEYHLTPECTLSTGLLEP ADPEGGCCWNPHCKQAVYFF SPAPDPRALLGGPRTVSYAV EFHPDTGDIIMEFRHADTPD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 513-692 of human PRMT7 (NP_061896.1). |
Additional Info
| Function | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3).such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro.the relevance of such results is however unclear in vivo. |
| Protein Name | Protein Arginine N-Methyltransferase 7Histone-Arginine N-Methyltransferase Prmt7Myelin Basic Protein-Arginine N-Methyltransferase Prmt7 |
| Database Links | Reactome: R-HSA-3214858 |
| Cellular Localisation | CytoplasmCytosolNucleus |
| Alternative Antibody Names | Anti-Protein Arginine N-Methyltransferase 7 antibodyAnti-Histone-Arginine N-Methyltransferase Prmt7 antibodyAnti-Myelin Basic Protein-Arginine N-Methyltransferase Prmt7 antibodyAnti-PRMT7 antibodyAnti-KIAA1933 antibody |
Information sourced from Uniprot.org