Anti-PRMT3 antibody (11-24 aa) [R01-7K2] (STJA0011831)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human PRMT3
General Information
| Short Description | Rabbit monoclonal anti-PRMT3 (11-24 aa) for use in WB, IHC-P and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-7K2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4ยฐC short term. Aliquot and store at-20ยฐC long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PRMT3 |
| Gene ID | 10196 |
| Uniprot ID | ANM3_HUMAN |
| Immunogen | A synthetic peptide of human PRMT3 |
| Immunogen Region | 11-24 aa |
Additional Info
| Function | Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases. Catalyzes the asymmetric arginine dimethylation at multiple sites in the Arg/Gly-rich region of small ribosomal subunit protein uS5/RPS2. Also appears to methylate other ribosomal proteins. May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity. Contributes to methylation of histone H4 'Arg-3', a specific tag for epigenetic transcriptional activation. Mediates asymmetric arginine dimethylation of histone H4 'Arg-3' (H4R3me2a) in the promoter region of miRNA miR-3648, to promote its transcription and osteogenesis. |
| Protein Name | Protein Arginine N-Methyltransferase 3Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 3 |
| Database Links | Reactome: R-HSA-3214858Reactome: R-HSA-8876725 |
| Cellular Localisation | CytoplasmCytosolNucleusLocalized To The Nucleus By Znf200 |
| Alternative Antibody Names | Anti-Protein Arginine N-Methyltransferase 3 antibodyAnti-Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-Like Protein 3 antibodyAnti-PRMT3 antibodyAnti-HRMT1L3 antibody |
Information sourced from Uniprot.org