Anti-PRG2 antibody (100-200) (STJ25110)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PRG2 (100-200) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRG2 |
| Gene ID | 5553 |
| Uniprot ID | PRG2_HUMAN |
| Immunogen Region | 100-200 |
| Immunogen Sequence | GIPGCQTCRYLLVRSLQTFS QAWFTCRRCYRGNLVSIHNF NINYRIQCSVSALNQGQVWI GGRITGSGRCRRFQWVDGSR WNFAYWAAHQPWSRGGHCVA L |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human PRG2 (NP_002719.3). |
Additional Info
| Tissue Specificity | Detected in plasma and urine (at protein level). Detected in placenta (at protein level). High levels of the proform in placenta and pregnancy serum.in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. |
| Post Translational Modifications | Nitrated. |
| Function | Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. |
| Protein Name | Bone Marrow ProteoglycanBmpgProteoglycan 2 Cleaved Into - Eosinophil Granule Major Basic ProteinEmbpMbpPregnancy-Associated Major Basic Protein |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Bone Marrow Proteoglycan: SecretedThe Proform Is SecretedEosinophil Granule Major Basic Protein: Cytoplasmic VesicleSecretory VesicleThe Mature Protein Is Found In The Matrix Of The Eosinophil's Large Specific Granule (Crystalloid Core) |
| Alternative Antibody Names | Anti-Bone Marrow Proteoglycan antibodyAnti-Bmpg antibodyAnti-Proteoglycan 2 Cleaved Into - Eosinophil Granule Major Basic Protein antibodyAnti-Embp antibodyAnti-Mbp antibodyAnti-Pregnancy-Associated Major Basic Protein antibodyAnti-PRG2 antibodyAnti-MBP antibody |
Information sourced from Uniprot.org