• Immunohistochemistry of baboon lung with Anti-PREX1 primary antibody (STJ502648) at 1:100 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-PREX1 antibody (815-836) (STJ502648)

SKU:
STJ502648-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Monkey/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PREX1 (815-836) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.6 µg/µl
Dilution Range: WB: 1:500-1:750
DB: 1:20, 000-1:50, 000
ELISA: 1:20, 000-1:50, 000
IP: 1:500
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PREX1
Gene ID: 57580
Uniprot ID: PREX1_HUMAN
Immunogen Region: 815-836
Immunogen: Synthetic peptide corresponding to aino acid region 815-836 of Human PREX1. Peptide was covalently modified.
Tissue Specificity Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
Function Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Protein Name Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 Protein
P-Rex1
Ptdins(3 -4 -5-Dependent Rac Exchanger 1
Database Links Reactome: R-HSA-193648
Reactome: R-HSA-416482
Reactome: R-HSA-8980692
Reactome: R-HSA-9013026
Reactome: R-HSA-9013106
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013406
Reactome: R-HSA-9013408
Reactome: R-HSA-9013409
Reactome: R-HSA-9013423
Cellular Localisation Cytoplasm
Cytosol
Cell Membrane
Mainly Cytosolic
Some Amount Is Apparently Associated To The Plasma Membrane
Alternative Antibody Names Anti-Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 Protein antibody
Anti-P-Rex1 antibody
Anti-Ptdins(3 -4 -5-Dependent Rac Exchanger 1 antibody
Anti-PREX1 antibody
Anti-KIAA1415 antibody

Information sourced from Uniprot.org

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