Anti-PREX1 antibody (1000-1300) (STJ11100299)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PREX1 (1000-1300) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PREX1 |
| Gene ID | 57580 |
| Uniprot ID | PREX1_HUMAN |
| Immunogen Region | 1000-1300 |
| Immunogen Sequence | PSLIGLDPEQGHLNPMSYTQ HCITTMAAPSWKCLPAAEGD PQGQGLHDGSFGPASGTLGQ EDRGLSFLLKQEDREIQDAY LQLFTKLDVALKEMKQYVTQ INRLLSTITEPTSGGSCDAS LAEEASSLPLVSEESEMDRS DHGGIKKVCFKVAEEDQEDS GHDTMSYRDSYSECNSNRDS VLSYTSVRSNSSYLGSDEMG SGDELPCDMRIPSDKQDKLH GCLEHLFNQVDSINALLKG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1300 of human PREX1 (NP_065871.2). |
Additional Info
| Tissue Specificity | Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. |
| Function | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Protein Name | Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 ProteinP-Rex1Ptdins(3 -4 -5-Dependent Rac Exchanger 1 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013406Reactome: R-HSA-9013408Reactome: R-HSA-9013409Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCytosolCell MembraneMainly CytosolicSome Amount Is Apparently Associated To The Plasma Membrane |
| Alternative Antibody Names | Anti-Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 Protein antibodyAnti-P-Rex1 antibodyAnti-Ptdins(3 -4 -5-Dependent Rac Exchanger 1 antibodyAnti-PREX1 antibodyAnti-KIAA1415 antibody |
Information sourced from Uniprot.org