| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PRDX5 (53-214) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:20-1:50 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PRDX5 |
| Gene ID: |
25824 |
| Uniprot ID: |
PRDX5_HUMAN |
| Immunogen Region: |
53-214 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 53-214 of human Peroxiredoxin 5 (PRDX5) (NP_036226.2). |
| Immunogen Sequence: |
MAPIKVGDAIPAVEVFEGEP GNKVNLAELFKGKKGVLFGV PGAFTPGCSKTHLPGFVEQA EALKAKGVQVVACLSVNDAF VTGEWGRAHKAEGKVRLLAD PTGAFGKETDLLLDDSLVSI FGNRRLKRFSMVVQDGIVKA LNVEPDGTGLTCSLAPNIIS QL |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | S-palmitoylated. Palmitoylation occurs on the active site, inhibiting its reactivity.therefore PRDX5 palmitoylation status determines its antioxidant capacity. Isoform Mitochondrial: S-palmitoylated. Depalmitoylated by ABHD10. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. |
| Protein Name | Peroxiredoxin-5 - MitochondrialAlu Corepressor 1Antioxidant Enzyme B166Aoeb166Liver Tissue 2d-Page Spot 71bPlpPeroxiredoxin VPrx-VPeroxisomal Antioxidant EnzymeTpx Type ViThioredoxin Peroxidase Pmp20Thioredoxin-Dependent Peroxiredoxin 5 |
| Database Links | Reactome: R-HSA-3299685Reactome: R-HSA-5628897 P30044-2 |
| Cellular Localisation | Isoform Mitochondrial: MitochondrionIsoform Cytoplasmic+Peroxisomal: CytoplasmPeroxisome MatrixImported Into Peroxisomes Via Peroxisomal Targeting Signal 1 Receptor Pex5 |
| Alternative Antibody Names | Anti-Peroxiredoxin-5 - Mitochondrial antibodyAnti-Alu Corepressor 1 antibodyAnti-Antioxidant Enzyme B166 antibodyAnti-Aoeb166 antibodyAnti-Liver Tissue 2d-Page Spot 71b antibodyAnti-Plp antibodyAnti-Peroxiredoxin V antibodyAnti-Prx-V antibodyAnti-Peroxisomal Antioxidant Enzyme antibodyAnti-Tpx Type Vi antibodyAnti-Thioredoxin Peroxidase Pmp20 antibodyAnti-Thioredoxin-Dependent Peroxiredoxin 5 antibodyAnti-PRDX5 antibodyAnti-ACR1 antibodyAnti-SBBI10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
