| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | S-palmitoylated. Palmitoylation occurs on the active site, inhibiting its reactivity.therefore PRDX5 palmitoylation status determines its antioxidant capacity. Isoform Mitochondrial: S-palmitoylated. Depalmitoylated by ABHD10. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. |
| Protein Name | Peroxiredoxin-5 - MitochondrialAlu Corepressor 1Antioxidant Enzyme B166Aoeb166Liver Tissue 2d-Page Spot 71bPlpPeroxiredoxin VPrx-VPeroxisomal Antioxidant EnzymeTpx Type ViThioredoxin Peroxidase Pmp20Thioredoxin-Dependent Peroxiredoxin 5 |
| Database Links | Reactome: R-HSA-3299685Reactome: R-HSA-5628897 P30044-2 |
| Cellular Localisation | Isoform Mitochondrial: MitochondrionIsoform Cytoplasmic+Peroxisomal: CytoplasmPeroxisome MatrixImported Into Peroxisomes Via Peroxisomal Targeting Signal 1 Receptor Pex5 |
| Alternative Antibody Names | Anti-Peroxiredoxin-5 - Mitochondrial antibodyAnti-Alu Corepressor 1 antibodyAnti-Antioxidant Enzyme B166 antibodyAnti-Aoeb166 antibodyAnti-Liver Tissue 2d-Page Spot 71b antibodyAnti-Plp antibodyAnti-Peroxiredoxin V antibodyAnti-Prx-V antibodyAnti-Peroxisomal Antioxidant Enzyme antibodyAnti-Tpx Type Vi antibodyAnti-Thioredoxin Peroxidase Pmp20 antibodyAnti-Thioredoxin-Dependent Peroxiredoxin 5 antibodyAnti-PRDX5 antibodyAnti-ACR1 antibodyAnti-SBBI10 antibody |
Information sourced from Uniprot.org
