| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S0MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRDX2 |
| Gene ID: | 7001 |
| Uniprot ID: | PRDX2_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Peroxiredoxin 2 (PRDX2) (P32119). |
| Immunogen Sequence: | MASGNARIGKPAPDFKATAV VDGAFKEVKLSDYKGKYVVL FFYPLDFTFVCPTEIIAFSN RAEDFRKLGCEVLGVSVDSQ FTHLAWINTPRKEGGLGPLN |
| Post Translational Modifications | The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). |
| Protein Name | Peroxiredoxin-2 Natural Killer Cell-Enhancing Factor B Nkef-B Prp Thiol-Specific Antioxidant Protein Tsa Thioredoxin Peroxidase 1 Thioredoxin-Dependent Peroxide Reductase 1 Thioredoxin-Dependent Peroxiredoxin 2 |
| Database Links | Reactome: R-HSA-3299685 Reactome: R-HSA-5628897 Reactome: R-HSA-8862803 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Peroxiredoxin-2 antibody Anti-Natural Killer Cell-Enhancing Factor B antibody Anti-Nkef-B antibody Anti-Prp antibody Anti-Thiol-Specific Antioxidant Protein antibody Anti-Tsa antibody Anti-Thioredoxin Peroxidase 1 antibody Anti-Thioredoxin-Dependent Peroxide Reductase 1 antibody Anti-Thioredoxin-Dependent Peroxiredoxin 2 antibody Anti-PRDX2 antibody Anti-NKEFB antibody Anti-TDPX1 antibody |
Information sourced from Uniprot.org