| Short Description : | Rabbit polyclonal PRDM6 (376-595) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRDM6 |
| Gene ID: | 93166 |
| Uniprot ID: | PRDM6_HUMAN |
| Immunogen Region: | 376-595 |
| Immunogen Sequence: | LQCIAQDENLNVPSTVMEAM CRQDALQPFNKSSKLAPTTQ QRSVVFPQTPCSRNFSLLDK SGPIESGFNQINVKNQRVLA SPTSTSQLHSEFSDWHLWKC GQCFKTFTQRILLQMHVCTQ NPDRPYQCGHCSQSFSQPSE LRNHVVTHSSDRPFKCGYCG RAFAGATTLNNHIRTHTGEK PFKCERCERSFTQATQLSRH QRMPNECKPITESPESIEVD |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 376-595 of human PRDM6 (NP_001129711.1). |
| Function | Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. |
| Protein Name | Putative Histone-Lysine N-Methyltransferase Prdm6Pr Domain Zinc Finger Protein 6Pr Domain-Containing Protein 6 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Putative Histone-Lysine N-Methyltransferase Prdm6 antibodyAnti-Pr Domain Zinc Finger Protein 6 antibodyAnti-Pr Domain-Containing Protein 6 antibodyAnti-PRDM6 antibodyAnti-PFM3 antibody |
Information sourced from Uniprot.org
