Function | Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development. Also plays a role in induced pluripotent stem cells (iPSCs) reprogramming. |
Protein Name | Pr Domain Zinc Finger Protein 15Pr Domain-Containing Protein 15Zinc Finger Protein 298 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Pr Domain Zinc Finger Protein 15 antibodyAnti-Pr Domain-Containing Protein 15 antibodyAnti-Zinc Finger Protein 298 antibodyAnti-PRDM15 antibodyAnti-C21orf83 antibodyAnti-ZNF298 antibody |
Information sourced from Uniprot.org