Anti-PRDM14 antibody (533-544) (STJ72515)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PRDM14 (533-544) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx 70kDa band observed in lysates of cell line A549 (calculated MW of 64.1kDa according to NP_078780.1). Recommended concentration: 1-3µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PRDM14 |
| Gene ID | 63978 |
| Uniprot ID | PRD14_HUMAN |
| Accession Number | NP_078780.1 |
| Immunogen Region | 533-544 |
| Immunogen Sequence | DSHVRRSHKEDD |
Additional Info
| Function | Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation. Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTCTCCTAA-3'. |
| Protein Name | Pr Domain Zinc Finger Protein 14Pr Domain-Containing Protein 14 |
| Database Links | Reactome: R-HSA-452723 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pr Domain Zinc Finger Protein 14 antibodyAnti-Pr Domain-Containing Protein 14 antibodyAnti-PRDM14 antibody |
Information sourced from Uniprot.org