| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PRDM14 (1-260) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PRDM14 |
| Gene ID: |
63978 |
| Uniprot ID: |
PRD14_HUMAN |
| Immunogen Region: |
1-260 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PRDM14 (NP_078780.1). |
| Immunogen Sequence: |
MALPRPSEAVPQDKVCYPPE SSPQNLAAYYTPFPSYGHYR NSLATVEEDFQPFRQLEAAA SAAPAMPPFPFRMAPPLLSP GLGLQREPLYDLPWYSKLPP WYPIPHVPREVPPFLSSSHE YAGASSEDLGHQIIGGDNES GPCCGPDTLIPPPPADASLL PEGLRTSQLLPCSPSKQSED GPKPSNQEGKSPARFQFTEE DLHFVLYGVTPSLEHPASLH HAISGLLVPPDSSGSDSLP |
| Tissue Specificity | Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level). |
| Function | Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation. Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTCTCCTAA-3'. |
| Protein Name | Pr Domain Zinc Finger Protein 14Pr Domain-Containing Protein 14 |
| Database Links | Reactome: R-HSA-452723 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pr Domain Zinc Finger Protein 14 antibodyAnti-Pr Domain-Containing Protein 14 antibodyAnti-PRDM14 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
