Anti-PRAME antibody [SQab30314] (STJ16103041)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
ImmunogenRecombinant protein of Human PRAME.
General Information
| Short Description | Rabbit monoclonal anti-PRAME for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SQab30314 |
| Conjugation | Unconjugated |
| Purification | Purification with Protein A. |
| Formulation | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
| Storage Instruction | Store at-20°C for up to 1 year. Minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PRAME |
| Gene ID | 23532 |
| Uniprot ID | PRAME_HUMAN |
| Immunogen | Recombinant protein of Human PRAME. |
Additional Info
| Function | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation. Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. |
| Protein Name | Melanoma Antigen Preferentially Expressed In TumorsOpa-Interacting Protein 4Oip-4Preferentially Expressed Antigen Of Melanoma |
| Database Links | |
| Cellular Localisation | NucleusChromosomeCytoplasmGolgi ApparatusCell MembraneAssociates With ChromatinSpecifically Enriched At Transcriptionally Active Promoters That Are Also Bound By Nuclear Transcription Factor Y (Composed Of NfyaNfyb And Nfyc) And At EnhancersRecruited To The Golgi Apparatus In Response To Interferon Gamma (Ifng) Treatment |
| Alternative Antibody Names | Anti-Melanoma Antigen Preferentially Expressed In Tumors antibodyAnti-Opa-Interacting Protein 4 antibodyAnti-Oip-4 antibodyAnti-Preferentially Expressed Antigen Of Melanoma antibodyAnti-PRAME antibodyAnti-MAPE antibodyAnti-OIP4 antibody |
Information sourced from Uniprot.org