| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PPP5C (1-210) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PPP5C |
| Gene ID: |
5536 |
| Uniprot ID: |
PPP5_HUMAN |
| Immunogen Region: |
1-210 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PPP5C (NP_006238.1). |
| Immunogen Sequence: |
MAMAEGERTECAEPPRDEPP ADGALKRAEELKTQANDYFK AKDYENAIKFYSQAIELNPS NAIYYGNRSLAYLRTECYGY ALGDATRAIELDKKYIKGYY RRAASNMALGKFRAALRDYE TVVKVKPHDKDAKMKYQECN KIVKQKAFERAIAGDEHKRS VVDSLDIESMTIEDEYSGPK LEDGKVTISFMKELMQWYKD QKKLHRKCAY |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form. |
| Function | Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2. Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90. |
| Protein Name | Serine/Threonine-Protein Phosphatase 5Pp5Protein Phosphatase TPp-TPpt |
| Database Links | Reactome: R-HSA-5675221Reactome: R-HSA-5693565Reactome: R-HSA-8939211 |
| Cellular Localisation | NucleusCytoplasmCell MembranePredominantly NuclearBut Also Present In The CytoplasmTranslocates From The Cytoplasm To The Plasma Membrane In A Rac1-Dependent Manner |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 5 antibodyAnti-Pp5 antibodyAnti-Protein Phosphatase T antibodyAnti-Pp-T antibodyAnti-Ppt antibodyAnti-PPP5C antibodyAnti-PPP5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
