Home
Primary Antibodies
Monoclonal Antibodies
Anti-PPP4C antibody [2F11-D10-G4] (STJ99049)

Immunocytochemistry of HeLa cells using anti-Protein Phosphatase 4C mouse mAb diluted 1:200.
IHC of paraffin-embedded human breast cancer using anti-Protein Phosphatase 4C mouse mAb diluted 1/500-1/1000.
Western blot detection of Protein Phosphatase 4C in Hela and Jurkat cell lysates using Protein Phosphatase 4C mouse mAb (1:200 diluted).Predicted band size: 34KDa.Observed band size: 34KDa.

Anti-PPP4C antibody [2F11-D10-G4] (STJ99049)

SKU:

STJ99049

£139.00 - £336.00

Current Stock:

General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Mouse
Applications:	WB/IHC/ICC
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Serine/threonine-protein phosphatase 4 catalytic subunit is suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry research applications.

Clonality:	Monoclonal
Clone ID:	2F11-D10-G4
Conjugation:	Unconjugated
Isotype:	IgG2a
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:200 ICC 1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	PPP4C
Gene ID:	5531
Uniprot ID:	PP4C_HUMAN
Specificity:	This antibody detects endogenous levels of Protein Phosphatase 4C and does not cross-react with related proteins.
Immunogen:	Purified recombinant human Protein Phosphatase 4C protein fragments expressed in E.coli.

Function	Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
Protein Name	Serine/Threonine-Protein Phosphatase 4 Catalytic Subunit Pp4c Pp4 Protein Phosphatase X Pp-X
Database Links	Reactome: R-HSA-5693607
Cellular Localisation	Cytoplasm Nucleus Cytoskeleton Microtubule Organizing Center Centrosome
Alternative Antibody Names	Anti-Serine/Threonine-Protein Phosphatase 4 Catalytic Subunit antibody Anti-Pp4c antibody Anti-Pp4 antibody Anti-Protein Phosphatase X antibody Anti-Pp-X antibody Anti-PPP4C antibody Anti-PPP4 antibody Anti-PPX antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

reviews