Anti-PPP2R5B antibody (400-497) (STJ11103926)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Beta Isoform (400-497) antibody for use in WB and ELISA in rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPP2R5B |
| Gene ID | 5526 |
| Uniprot ID | 2A5B_HUMAN |
| Immunogen Region | 400-497 |
| Immunogen Sequence | AVFGTLYQVSKEHWNQTIVS LIYNVLKTFMEMNGKLFDEL TASYKLEKQQEQQKAQERQE LWQGLEELRLRRLQGTQGAK EAPLQRLTPQVAASGGQS |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 400-497 of human PP2A-B56 Beta/PR61 Beta/PPP2R5B (NP_006235.1). |
Additional Info
| Tissue Specificity | Highest expression in brain. |
| Post Translational Modifications | Ubiquitinated by E3 CUL3-KLHL15 complex.this modification leads to proteasomal degradation. |
| Function | As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Beta IsoformPp2a B Subunit Isoform B'-BetaPp2a B Subunit Isoform B56-BetaPp2a B Subunit Isoform Pr61-BetaPp2a B Subunit Isoform R5-Beta |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-381038Reactome: R-HSA-389356Reactome: R-HSA-389513Reactome: R-HSA-432142Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-5663220Reactome: R-HSA-5673000Reactome: R-HSA-5675221Reactome: R-HSA-6811558Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Beta Isoform antibodyAnti-Pp2a B Subunit Isoform B'-Beta antibodyAnti-Pp2a B Subunit Isoform B56-Beta antibodyAnti-Pp2a B Subunit Isoform Pr61-Beta antibodyAnti-Pp2a B Subunit Isoform R5-Beta antibodyAnti-PPP2R5B antibody |
Information sourced from Uniprot.org