Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: | Monoclonal |
Clone ID: | S5300RM |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:2000-1:8000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | PPP2R2A |
Gene ID: | 5520 |
Uniprot ID: | 2ABA_HUMAN |
Immunogen Region: | 94-194 |
Specificity: | A synthetic peptide corresponding to a sequence within amino acids 94-194 of human PP2A-B55 Alpha/PR55 Alpha/PPP2R2A (NP_002708.1). |
Immunogen Sequence: | EKINKIRWLPQKNAAQFLLS TNDKTIKLWKISERDKRPEG YNLKEEDGRYRDPTTVTTLR VPVFRPMDLMVEASPRRIFA NAHTYHINSISINSDYETYL S |
Tissue Specificity | Expressed in all tissues examined. |
Function | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. |
Protein Name | Serine/Threonine-Protein Phosphatase 2a 55 Kda Regulatory Subunit B Alpha Isoform Pp2a Subunit B Isoform B55-Alpha Pp2a Subunit B Isoform Pr55-Alpha Pp2a Subunit B Isoform R2-Alpha Pp2a Subunit B Isoform Alpha |
Database Links | Reactome: R-HSA-2995383 Reactome: R-HSA-69231 Reactome: R-HSA-69273 Reactome: R-HSA-975957 |
Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2a 55 Kda Regulatory Subunit B Alpha Isoform antibody Anti-Pp2a Subunit B Isoform B55-Alpha antibody Anti-Pp2a Subunit B Isoform Pr55-Alpha antibody Anti-Pp2a Subunit B Isoform R2-Alpha antibody Anti-Pp2a Subunit B Isoform Alpha antibody Anti-PPP2R2A antibody |
Information sourced from Uniprot.org