Anti-PPP2R2A antibody (100-447) (STJ115491)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PPP2R2A (100-447) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPP2R2A |
| Gene ID | 5520 |
| Uniprot ID | 2ABA_HUMAN |
| Immunogen Region | 100-447 |
| Immunogen Sequence | RWLPQKNAAQFLLSTNDKTI KLWKISERDKRPEGYNLKEE DGRYRDPTTVTTLRVPVFRP MDLMVEASPRRIFANAHTYH INSISINSDYETYLSADDLR I |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human PP2A-B55 Alpha/PR55 Alpha/PPP2R2A (NP_002708.1). |
Additional Info
| Tissue Specificity | Expressed in all tissues examined. |
| Function | Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a 55 Kda Regulatory Subunit B Alpha IsoformPp2a Subunit B Isoform B55-AlphaB55Pp2a Subunit B Isoform Pr55-AlphaPp2a Subunit B Isoform R2-AlphaPp2a Subunit B Isoform Alpha |
| Database Links | Reactome: R-HSA-2995383Reactome: R-HSA-69231Reactome: R-HSA-69273Reactome: R-HSA-975957Reactome: R-HSA-9860927 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2a 55 Kda Regulatory Subunit B Alpha Isoform antibodyAnti-Pp2a Subunit B Isoform B55-Alpha antibodyAnti-B55 antibodyAnti-Pp2a Subunit B Isoform Pr55-Alpha antibodyAnti-Pp2a Subunit B Isoform R2-Alpha antibodyAnti-Pp2a Subunit B Isoform Alpha antibodyAnti-PPP2R2A antibody |
Information sourced from Uniprot.org