| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Serine/Threonine-Protein Phosphatase 2a 55 Kda Regulatory Subunit B Alpha Isoform (94-194) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S5300RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PPP2R2A |
| Gene ID: |
5520 |
| Uniprot ID: |
2ABA_HUMAN |
| Immunogen Region: |
94-194 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 94-194 of human PP2A-B55alpha/PR55alpha/PPP2R2A (NP_002708.1). |
| Immunogen Sequence: |
EKINKIRWLPQKNAAQFLLS TNDKTIKLWKISERDKRPEG YNLKEEDGRYRDPTTVTTLR VPVFRPMDLMVEASPRRIFA NAHTYHINSISINSDYETYL S |
| Tissue Specificity | Expressed in all tissues examined. |
| Function | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a 55 Kda Regulatory Subunit B Alpha IsoformPp2a Subunit B Isoform B55-AlphaPp2a Subunit B Isoform Pr55-AlphaPp2a Subunit B Isoform R2-AlphaPp2a Subunit B Isoform Alpha |
| Database Links | Reactome: R-HSA-2995383Reactome: R-HSA-69231Reactome: R-HSA-69273Reactome: R-HSA-975957 |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2a 55 Kda Regulatory Subunit B Alpha Isoform antibodyAnti-Pp2a Subunit B Isoform B55-Alpha antibodyAnti-Pp2a Subunit B Isoform Pr55-Alpha antibodyAnti-Pp2a Subunit B Isoform R2-Alpha antibodyAnti-Pp2a Subunit B Isoform Alpha antibodyAnti-PPP2R2A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
