Anti-PPP1R3B antibody (1-140) (STJ117130)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PPP1R3B (1-140) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPP1R3B |
| Gene ID | 79660 |
| Uniprot ID | PPR3B_HUMAN |
| Immunogen Region | 1-140 |
| Immunogen Sequence | MMAVDIEYRYNCMAPSLRQE RFAFKISPKPSKPLRPCIQL SSKNEASGMVAPAVQEKKVK KRVSFADNQGLALTMVKVFS EFDDPLDMPFNITELLDNIV SLTTAESESFVLDFSQPSAD YLDFRNRLQADHVCLENCVL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human PPP1R3B (NP_078883.2). |
Additional Info
| Tissue Specificity | Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver and heart. Weak expression in placenta and lung. |
| Function | Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes. |
| Protein Name | Protein Phosphatase 1 Regulatory Subunit 3bHepatic Glycogen-Targeting Protein Phosphatase 1 Regulatory Subunit GlProtein Phosphatase 1 Regulatory Subunit 4Pp1 Subunit R4Protein Phosphatase 1 Subunit GlPtg |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Protein Phosphatase 1 Regulatory Subunit 3b antibodyAnti-Hepatic Glycogen-Targeting Protein Phosphatase 1 Regulatory Subunit Gl antibodyAnti-Protein Phosphatase 1 Regulatory Subunit 4 antibodyAnti-Pp1 Subunit R4 antibodyAnti-Protein Phosphatase 1 Subunit Gl antibodyAnti-Ptg antibodyAnti-PPP1R3B antibodyAnti-PPP1R4 antibody |
Information sourced from Uniprot.org