Anti-PPP1R12B antibody (660-930) (STJ119602)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PPP1R12B (660-930) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPP1R12B |
| Gene ID | 4660 |
| Uniprot ID | MYPT2_HUMAN |
| Immunogen Region | 660-930 |
| Immunogen Sequence | TFSRSRAERQAQEQPREKPT DTEGLEGSPEKHEPSAVPAT EAGEGQQPWGRSLDEEPICH RLRCPAQPDKPTTPASPSTS RPSLYTSSHLLWTNRFSVPD SESSETTTNTTTAKEMDKNE NEEADLDEQSSKRLSIRERR RPKERRRGTGINFWTKDEDE TDGSEEVKETWHERLSRLES GGSNPTTSDSYGDRASARAR REAREARLATLTSRVEEDSN RDYKKLYESALTENQKLKT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 660-930 of human PPP1R12B (NP_002472.2). |
Additional Info
| Tissue Specificity | Detected in skeletal muscle, fetal and adult heart, brain, placenta, kidney, spleen, thymus, pancreas and lung. Isoform 3 and isoform 4 are heart specific. |
| Function | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. |
| Protein Name | Protein Phosphatase 1 Regulatory Subunit 12bMyosin Phosphatase-Targeting Subunit 2Myosin Phosphatase Target Subunit 2 |
| Database Links | Reactome: R-HSA-2565942 O60237-4Reactome: R-HSA-5625740Reactome: R-HSA-5625900Reactome: R-HSA-5627117Reactome: R-HSA-5627123 |
| Cellular Localisation | CytoplasmCytoskeletonStress FiberAlong Actomyosin Filaments |
| Alternative Antibody Names | Anti-Protein Phosphatase 1 Regulatory Subunit 12b antibodyAnti-Myosin Phosphatase-Targeting Subunit 2 antibodyAnti-Myosin Phosphatase Target Subunit 2 antibodyAnti-PPP1R12B antibodyAnti-MYPT2 antibody |
Information sourced from Uniprot.org