Anti-PPM1D antibody [7E11/C5] (STJ16103386)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified human PPM1D
General Information
| Short Description | Mouse monoclonal anti-PPM1D for use in WB, IHC-P, ICC and ELISA in Mouse and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/ELISA |
| Host | Mouse |
| Reactivity | Mouse/Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 7E11/C5 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by protein-A affinity chromatography. |
| Formulation | Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | PPM1D |
| Gene ID | 8493 |
| Uniprot ID | PPM1D_HUMAN |
| Immunogen | Purified human PPM1D |
Additional Info
| Function | Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity. |
| Protein Name | Protein Phosphatase 1dProtein Phosphatase 2c Isoform DeltaPp2c-DeltaProtein Phosphatase Magnesium-Dependent 1 DeltaP53-Induced Protein Phosphatase 1 |
| Database Links | Reactome: R-HSA-8878166 |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative Antibody Names | Anti-Protein Phosphatase 1d antibodyAnti-Protein Phosphatase 2c Isoform Delta antibodyAnti-Pp2c-Delta antibodyAnti-Protein Phosphatase Magnesium-Dependent 1 Delta antibodyAnti-P53-Induced Protein Phosphatase 1 antibodyAnti-PPM1D antibodyAnti-WIP1 antibody |
Information sourced from Uniprot.org