Anti-PPM1D antibody [30] (STJA0032736)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant human PPM1D protein fragments expressed in E.coli.
General Information
| Short Description | Mouse monoclonal anti-PPM1D for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 30 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PPM1D |
| Gene ID | 8493 |
| Uniprot ID | PPM1D_HUMAN |
| Immunogen | Purified recombinant human PPM1D protein fragments expressed in E.coli. |
Additional Info
| Tissue Specificity | Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts. |
| Function | Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity. |
| Protein Name | Protein Phosphatase 1dProtein Phosphatase 2c Isoform DeltaPp2c-DeltaProtein Phosphatase Magnesium-Dependent 1 DeltaP53-Induced Protein Phosphatase 1 |
| Database Links | Reactome: R-HSA-8878166 |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative Antibody Names | Anti-Protein Phosphatase 1d antibodyAnti-Protein Phosphatase 2c Isoform Delta antibodyAnti-Pp2c-Delta antibodyAnti-Protein Phosphatase Magnesium-Dependent 1 Delta antibodyAnti-P53-Induced Protein Phosphatase 1 antibodyAnti-PPM1D antibodyAnti-WIP1 antibody |
Information sourced from Uniprot.org