| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ring-Type E3 Ubiquitin-Protein Ligase Ppil2 (1-260) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PPIL2 |
| Gene ID: |
23759 |
| Uniprot ID: |
PPIL2_HUMAN |
| Immunogen Region: |
1-260 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PPIL2 (NP_680481.1). |
| Immunogen Sequence: |
MGKRQHQKDKMYITCAEYTH FYGGKKPDLPQTNFRRLPFD HCSLSLQPFVYPVCTPDGIV FDLLNIVPWLKKYGTNPSNG EKLDGRSLIKLNFSKNSEGK YHCPVLFTVFTNNTHIVAVR TTGNVYAYEAVEQLNIKAKN FRDLLTDEPFSRQDIITLQD PTNLDKFNVSNFYHVKNNMK IIDPDEEKAKQDPSYYLKNT NAETRETLQELYKEFKGDEI LAATMKAPEKKKVDKLNAA |
| Tissue Specificity | Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland. Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas. |
| Function | Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). |
| Protein Name | Ring-Type E3 Ubiquitin-Protein Ligase Ppil2Cyc4Cyclophilin-60Cyclophilin-Like Protein Cyp-60Cyp60Hcyp-60Probable Inactive Peptidyl-Prolyl Cis-Trans Isomerase-Like 2PpiaseRotamase Ppil2 |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusMay Also Localize To The Cytoplasm And The Cell Membrane |
| Alternative Antibody Names | Anti-Ring-Type E3 Ubiquitin-Protein Ligase Ppil2 antibodyAnti-Cyc4 antibodyAnti-Cyclophilin-60 antibodyAnti-Cyclophilin-Like Protein Cyp-60 antibodyAnti-Cyp60 antibodyAnti-Hcyp-60 antibodyAnti-Probable Inactive Peptidyl-Prolyl Cis-Trans Isomerase-Like 2 antibodyAnti-Ppiase antibodyAnti-Rotamase Ppil2 antibodyAnti-PPIL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
