Anti-PPARD antibody (101-200 aa) (STJ11107104)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PPARD (101-200 aa) antibody for use in WB and ELISA in rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPARD |
| Gene ID | 5467 |
| Uniprot ID | PPARD_HUMAN |
| Immunogen Region | 101-200 aa |
| Immunogen Sequence | TIRMKLEYEKCERSCKIQKK NRNKCQYCRFQKCLALGMSH NAIRFGRMPEAEKRKLVAGL TANEGSQYNPQVADLKAFSK HIYNAYLKNFNMTKKKARSI |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 101-200 of human PPARD (NP_006229.1). |
Additional Info
| Tissue Specificity | Ubiquitous with maximal levels in placenta and skeletal muscle. |
| Post Translational Modifications | 'Lys-48'-linked polyubiquitinated.leading to proteasomal degradation. Deubiquitinated and stabilized by OTUD3. |
| Function | Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. |
| Protein Name | Peroxisome Proliferator-Activated Receptor DeltaPpar-DeltaNuciNuclear Hormone Receptor 1Nuc1Nuclear Receptor Subfamily 1 Group C Member 2Peroxisome Proliferator-Activated Receptor BetaPpar-Beta |
| Database Links | Reactome: R-HSA-200425Reactome: R-HSA-383280Reactome: R-HSA-5362517 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Peroxisome Proliferator-Activated Receptor Delta antibodyAnti-Ppar-Delta antibodyAnti-Nuci antibodyAnti-Nuclear Hormone Receptor 1 antibodyAnti-Nuc1 antibodyAnti-Nuclear Receptor Subfamily 1 Group C Member 2 antibodyAnti-Peroxisome Proliferator-Activated Receptor Beta antibodyAnti-Ppar-Beta antibodyAnti-PPARD antibodyAnti-NR1C2 antibodyAnti-PPARB antibody |
Information sourced from Uniprot.org