Anti-PP2C alpha/PPM1A antibody (1-382aa) [p6C7] (STJA0041902)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenRecombinant human PP2Calpha/PPM1A (1-382aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-PP2C alpha/PPM1A (1-382aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | p6C7 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPM1A |
| Gene ID | 5494 |
| Uniprot ID | PPM1A_HUMAN |
| Accession Number | NP_066283 |
| Immunogen | Recombinant human PP2Calpha/PPM1A (1-382aa) purified from E. coli |
| Immunogen Region | 1-382aa |
Additional Info
| Post Translational Modifications | N-myristoylation is essential for the recognition of its substrates for dephosphorylation. |
| Function | Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. |
| Protein Name | Protein Phosphatase 1aProtein Phosphatase 2c Isoform AlphaPp2c-AlphaProtein Phosphatase Ia |
| Database Links | Reactome: R-HSA-2173795Reactome: R-HSA-380972 |
| Cellular Localisation | NucleusCytoplasmCytosolMembraneLipid-AnchorWeakly Associates At The Membrane And N-Myristoylation Mediates The Membrane Localization |
| Alternative Antibody Names | Anti-Protein Phosphatase 1a antibodyAnti-Protein Phosphatase 2c Isoform Alpha antibodyAnti-Pp2c-Alpha antibodyAnti-Protein Phosphatase Ia antibodyAnti-PPM1A antibodyAnti-PPPM1A antibody |
Information sourced from Uniprot.org