Anti-PP2A-gamma antibody (390-439) {Biotin} (STJ505957)

SKU:
STJ505957-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PP2A-gamma (390-439) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PPP2R5C
Gene ID: 5527
Uniprot ID: 2A5G_HUMAN
Immunogen Region: 390-439
Immunogen: Synthetic peptide taken within amino acid region 390-439 on human Serine/Threonine-Protein Phosphatase 2A B56 Gamma1 subunit.
Post Translational Modifications Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C.
Function The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
Protein Name Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Gamma Isoform
Pp2a B Subunit Isoform B'-Gamma
Pp2a B Subunit Isoform B56-Gamma
Pp2a B Subunit Isoform Pr61-Gamma
Pp2a B Subunit Isoform R5-Gamma
Renal Carcinoma Antigen Ny-Ren-29
Database Links Reactome: R-HSA-141444
Reactome: R-HSA-195253
Reactome: R-HSA-196299
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-389513
Reactome: R-HSA-432142
Reactome: R-HSA-4641262
Reactome: R-HSA-5339716
Reactome: R-HSA-5358747
Reactome: R-HSA-5358749
Reactome: R-HSA-5358751
Reactome: R-HSA-5358752
Reactome: R-HSA-5467337
Reactome: R-HSA-5467340
Reactome: R-HSA-5467348
Reactome: R-HSA-5663220
Reactome: R-HSA-5673000
Reactome: R-HSA-5675221
Reactome: R-HSA-6804757
Reactome: R-HSA-6811558
Reactome: R-HSA-68877
Reactome: R-HSA-9648025
Cellular Localisation Nucleus
Chromosome
Centromere
Alternative Antibody Names Anti-Serine/Threonine-Protein Phosphatase 2a 56 Kda Regulatory Subunit Gamma Isoform antibody
Anti-Pp2a B Subunit Isoform B'-Gamma antibody
Anti-Pp2a B Subunit Isoform B56-Gamma antibody
Anti-Pp2a B Subunit Isoform Pr61-Gamma antibody
Anti-Pp2a B Subunit Isoform R5-Gamma antibody
Anti-Renal Carcinoma Antigen Ny-Ren-29 antibody
Anti-PPP2R5C antibody
Anti-KIAA0044 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance