| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-POU2AF1 (1-256) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POU2AF1 |
| Gene ID: |
5450 |
| Uniprot ID: |
OBF1_HUMAN |
| Immunogen Region: |
1-256 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-256 of human POU2AF1 (NP_006226.2). |
| Immunogen Sequence: |
MLWQKPTAPEQAPAPARPYQ GVRVKEPVKELLRRKRGHAS SGAAPAPTAVVLPHQPLATY TTVGPSCLDMEGSVSAVTEE AALCAGWLSQPTPATLQPLA PWTPYTEYVPHEAVSCPYSA DMYVQPVCPSYTVVGPSSVL TYASPPLITNVTTRSSATPA VGPPLEGPEHQAPLTYFPWP QPLSTLPTSTLQYQPPAPAL PGPQFVQLPISIPEPVLQDM EDPRRAASSLTIDKLLLEE |
| Tissue Specificity | B-cell specific. Detected in mainly in spleen, but also in thymus, periphral blood leukocyte and small intestine. |
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. |
| Function | Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator. |
| Protein Name | Pou Domain Class 2-Associating Factor 1B-Cell-Specific Coactivator Obf-1Bob-1Oca-BOct-Binding Factor 1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pou Domain Class 2-Associating Factor 1 antibodyAnti-B-Cell-Specific Coactivator Obf-1 antibodyAnti-Bob-1 antibodyAnti-Oca-B antibodyAnti-Oct-Binding Factor 1 antibodyAnti-POU2AF1 antibodyAnti-BOB1 antibodyAnti-OBF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
