Anti-PON3 antibody (250-350) (STJ118846)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PON3 (250-350) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PON3 |
| Gene ID | 5446 |
| Uniprot ID | PON3_HUMAN |
| Immunogen Region | 250-350 |
| Immunogen Sequence | HDNWDLTQLKVIQLGTLVDN LTVDPATGDILAGCHPNPMK LLNYNPEDPPGSEVLRIQNV LSEKPRVSTVYANNGSVLQG TSVASVYHGKILIGTVFHKT L |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PON3 (NP_000931.1). |
Additional Info
| Post Translational Modifications | The signal sequence is not cleaved. |
| Function | Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. |
| Protein Name | Serum Paraoxonase/Lactonase 3 |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-9754706 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Serum Paraoxonase/Lactonase 3 antibodyAnti-PON3 antibody |
Information sourced from Uniprot.org